12/10/2021

Scientist, Oncology Research

About Aktis Oncology

Aktis Oncology is a biotechnology company pioneering the discovery and development of a new class of targeted radiopharmaceuticals to treat a broad range of solid tumor cancers. Founded and incubated by MPM Capital with its seasoned team of entrepreneurs and drug developers, Aktis has developed proprietary platforms to generate tumor targeting agents with ideal properties for radiotherapy. Designed for high tumor penetration and long residence time, Aktis Oncology’s molecules can quickly clear other areas of the body, thereby maximizing tumor elimination while minimizing side effects of treatment. These are therapies that would also enable clinicians to visualize and verify target engagement prior to exposure to therapeutic radioisotopes.

Description

The role within Oncology Research will work in cross-functional teams to identify and develop novel therapies to treat targeted patient populations within multiple oncology indications. Under minimal supervision, the candidate will conduct laboratory experiments, interpret data and contribute to project goals as part of the Oncology Research Team.

Background/Training

  • BS/MS/MA in biological sciences or related field, preferably related to cancer biology, pharmacology or related field
  • 2-8 years of biopharmaceutical research experience in drug discovery and/or translational research

Experience/Accomplishments

  • Strong technical background in planning, designing and executing pre-clinical in vitro (required) and in vivo (preferred) experiments in order to evaluate target biology and characterize the efficacy and safety of development candidates
    • Desired expertise include:
      • Imaging, microscopy or pathology experience that can be leveraged to examine target expression across cell lines and/or tissue sections
      • Mammalian cell culture / cell line engineering
      • Common molecular and biochemical techniques (DNA/RNA isolation, qPCR, Western, ELISA, antibody characterization and QC, etc.)
    • Demonstrated experience in the adoption of new technologies and dissemination of information to colleagues for deployment across programs / initiatives
  • Experience with evaluation of target biology including but not limited to
    • Biophysical characterization of targets
      • Subcellular / tissue localization
      • Target:ligand interactions
      • Target density evaluation
    • Ex vivo examination of tumor samples
    • Evaluation of target engagement and proof-of-biology marks in vivo
  • Demonstrated success in the area of target discovery, target evaluation or drug discovery, translational research and integration with matrixed project teams
  • Demonstrated ability to gather relevant information systematically, break down problems into simple components and make sound decisions
  • Willingness to take on new challenges and build a culture of rigor and data-driven decision making to bring novel therapies to the clinic
  • Effectively communicates and collaborates with other R&D team members and collaborators to progress development candidate compounds
  • Demonstrated high standards for scientific rigor, team behaviors, excellence and building a culture of innovation that is fully aligned with company objectives
  • Demonstrated tenacity and drive for enterprise benefit
  • Position title to be finalized commensurate with experience and accomplishments

How to Apply

Please submit your cover letter and resume to recruitment@aktisoncology.com.