Advancing a novel pipeline addressing large patient populations

Our platform capabilities have generated a pipeline of targeted radiopharmaceutical programs to address unmet needs in prevalent solid tumors.

Pipeline

Program	Target/Indication	Discovery	IND-enabling	Phase 1b	Phase 2/3
	Nectin-4 expressing solid tumors
AKY-1189 was generated using our miniprotein radioconjugate platform and is designed to deliver ²²⁵Ac, a highly potent alpha-emitting radioisotope, to Nectin-4 expressing tumors. Our AKY-1189 program is targeting locally advanced or metastatic UC, breast cancer, NSCLC, colorectal cancer and cervical cancer. Currently in a multi-site Phase 1b study: NCT07020117
	B7-H3 expressing solid tumors
AKY-2519 was generated using our miniprotein radioconjugate platform and is designed to deliver ²²⁵Ac, a highly potent alpha-emitting radioisotope, to B7-H3 CD276 expressing tumors. Our AKY-2519 program is targeting prostate, lung and other solid tumors. Currently in IND-enabling studies.
Multiple Programs	Undisclosed
	Undisclosed

Presentations & Publications

02/27/2026

Poster presentation at the ASCO Genitourinary Cancers Symposium titled, “[225Ac]Ac-AKY-1189, a Nectin-4-Targeted Radiopharmaceutical, in Patients With Previously Treated Locally Advanced or Metastatic Solid Tumors: Phase 1b NECTINIUM-2 Study”

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10/25/2024

Oral Presentation at the EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics 2024 titled, “AKY-1189, a novel, ﬁrst-in-class miniprotein radiopharmaceutical designed to deliver Actinium-225 (225Ac) to Nectin-4 expressing tumors with broad therapeutic applications in metastatic urothelial carcinoma (mUC) and other Nectin-4 expressing tumors.”

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10/25/2024

Poster Presentation at the EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics 2024 titled, “Discovery and pre-clinical development of AKY-1189, a potent and selective Nectin-4 miniprotein binder optimized for use as a targeted radiopharmaceutical.”

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Scientist in lab coat holding a test tube and beaker